Sunday, July 28, 2024 1:30 PM – 4:30 PM US Central Time McCormick Place Chicago
This course is an introduction to the skill set needed for troubleshooting LC-MS/MS-based laboratory developed tests (LDTs) and production batches. The course incorporates lectures and case history discussion in break out groups. Details of sample preparation flaws, common LC method errors and MS/MS detection pitfalls will be presented and basics of LC and MS/MS theory as they apply to method development will be reviewed as needed. Further, the interpretation of chromatograms, LC pressure traces and system suitability tests will be discussed. Examples will be shown of maintenance calendar annotation, service reports, batch documentation and longitudinal chromatogram overlays (within batch and between day) as tools for pinpointing method and process weak points. In breakout sessions, attendees will discuss a case history of instrument or reporting failures sourced to suboptimal LC-MS/MS method design/implementation.
This activity is designed for lab supervisors, lab directors (and/or assistant directors),medical technologists, toxicologists, and in-training individuals.
Previous exposure to clinical LC-MS/MS testing and an understanding of the principles of sample preparation, liquid chromatography and tandem mass spectrometry.
N/A
Deborah French, PhD, DABCC, FADLM | University of California, San Francisco
Grace van der Gugten, BS | Alberta Precision Labs
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