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AACC is proud to announce the following Plenary sessions to be held each day, Sunday – Thursday. These thought-provoking lectures are delivered by world-renowned experts and cover timely topics spanning the breadth of laboratory medicine. Participants can also join Plenary speakers in the small and more intimate Meet-the-Expert sessions that follow to ask questions and meet the experts in the field.
Biomedical Informatics Strategies to Enhance Individualized Predictive Models
Lucila Ohno-Machado, MBA, MD, PhD Professor and Chair, Department of Biomedical Informatics Health Associate Dean, Informatics and Technology University of California San Diego
Precision medicine is based on the development of individualized estimates for patients. There is an increasing use of artificial intelligence (AI) in clinical prediction models (e.g., severity scores, sepsis prediction). Although adoption is still sparse among clinicians, we may soon have a long list of predictive models for a given problem and may have a difficult time deciding which one is best. In this plenary session, Dr. Ohno-Machado will introduce how AI models are developed, tested, and validated. Dr. Ohno-Machado will then discuss performance measures that may help clinicians select these models for routine use. This will be presented in a tutorial format that reviews the main differences between statistical models (e.g., regression) and AI models (e.g., neural networks), and describes how different evaluation measures including model simplicity, explainability, and classification performance can be assessed and compared. The goal is to demystify AI for clinicians and biomedical researchers.
2022 Wallace H. Coulter Lectureship Awardee
Multiplexed & Exponentially Improving Technologies
George Church, PhD Founding Core Faculty & Lead, Synthetic Biology Wyss Institute, Harvard University Professor of Genetics, Harvard Medical School Professor of Health Sciences and Technology, Harvard/Massachusetts Institute of Technology
Despite the 50-million-fold reduction in cost and comparable improvements in quality, we are just beginning to catch up with the implications of multiplexed sequencing and imaging. Through the advances in multiplexed sequencing and imaging, we can Identify small but crucial differences in DNA, RNA, proteins, and more at the population scale as well as at subcellular resolution. In this plenary session, Dr. George Church, AACC’s 2022 Wallace H. Coulter Lectureship Awardee and pioneer in personal genomics and synthetic biology, will discuss advances and implications of multiplex technologies.
Applications of Human Brain Organoid Technology
Alysson R. Muotri, PhD Professor of Pediatrics Professor of Cellular & Molecular Medicine University of California San Diego School of Medicine
The human brain is a very complex biological system and responsible for several neurological and neurodegenerative disorders, affecting millions of people worldwide. Despite its importance, the human brain is poorly understood due to the inaccessibility of the developmental stages in uterus. Participants of this plenary session will learn the concept of human brain organogenesis, or to put in other words, how to recreate the human brain in a dish. Several applications of this technology in medicine and engineering will be discussed.
Building Trust in a Time of Turmoil
Thomas H. Lee, MSc, MD Chief Medical Officer, Press Ganey Associates, LLC Professor of Medicine, Harvard Medical School/Brigham & Women's Hospital Professor of Health Policy and Management, Harvard T.H. Chan School of Public Health
The United States and rest of the world is having a trust crisis, which is affecting healthcare delivery along with most other parts of life. In this plenary session, Dr. Thomas Lee will describe the importance of building trust among patients and among the healthcare workforce. He will describe a three-component model for building trust, and the types of interventions most likely to be effective.
Guiding Clinical Decisions with Molecular Information Provided by Direct Mass Spectrometry Technologies
Livia Schiavinato Eberlin, PhD Associate Professor of Surgery Director, Translational and Innovations Research Baylor College of Medicine
Mass spectrometry techniques that allow direct and fast molecular analysis of clinical samples offer the exciting opportunity to incorporate molecular data into clinical practice to expedite clinical decision making and thus improve disease diagnosis and patient care. In this plenary session, Dr. Eberlin will discuss the development and application of direct mass spectrometry techniques used in clinical microbiology labs, clinical pathology labs, and the operating room. Key operational principles, depth of molecular data, and the analytical and diagnostic performance metrics achieved with these techniques for disease detection will be discussed to provide a critical assessment of their capabilities and potential uses within the context of routine clinical practice. The presentation will focus on results obtained in ongoing clinical studies employing two direct mass spectrometry techniques, desorption electrospray ionization mass spectrometry imaging and the MasSpec Pen technology. Challenges and opportunities in implementing these techniques into clinical workflows will also be discussed.
Join us in Chicago, July 24-28 to explore the cutting-edge science and technology shaping the future of laboratory medicine.
2022 AACC offers something for everyone in laboratory medicine, from Plenaries featuring world-renowned scientists to intimate Roundtables.
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