LC-MS Toxicology Workstreams, Orbitrap Technology, and Intuitive Software Enable Confident, Concise, and Comprehensive Results in Drug Analysis

Supported by Thermo Fisher Scientific

Overview

Part 1: The Thermo Scientific Tox Explorer Collection: Robust LC-MS Workstream for Toxicology Analysis. This presentation will demonstrate a targeted screening and quantitation method for a large panel of drugs of abuse. This workstream based approach utilizes the high-resolution, accurate-mass Thermo Scientific Q Exactive Plus Orbitrap mass spectrometer. Identified drugs are screened against an extensive HRAM MS/MS spectral library and a database containing molecular formula, exact mass, retention times, and fragment ions.

Part 2: Thermo Scientific TraceFinder Software Overview and Implementation of a Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer for the Identification and Quantitation of Synthetic Cannabinoids in Postmortem Forensic Investigations. Synthetic cannabinoids continue to appear in forensic toxicology casework, and they represent a chemically diverse class of substances with particularly difficult behaviors to which high resolution mass spectrometry (HRMS) can provide great benefit. A quantitative confirmatory test was developed and validated for 5F-MDMB-PICA (the most prevalent synthetic cannabinoid identified in forensic casework) and its metabolites in human blood. A Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer was used for analysis. This interactive presentation will provide an overview of TraceFinder software along with a review of the performance characteristics to demonstrate the utility and accuracy of the developed assay.

Presenters Part 1

Deb Bhattacharyya, PhD
Senior Manager, Vertical Marketing
Thermo Fisher Scientific

Kristine Van Natta, PhD
Strategic Marketing Applications Specialist
Thermo Fisher Scientific

Presenters Part 2

Tais Regina Fiorentin, PhD
Research Scientist II
The Center for Forensic Science Research and Education

Alex Krotulski, PhD
Research Scientist III
The Center for Forensic Science Research and Education