Supported by Thermo Fisher Scientific
Part 1: The Thermo Scientific Tox Explorer Collection: Robust LC-MS Workstream for Toxicology Analysis. This presentation will demonstrate a targeted screening and quantitation method for a large panel of drugs of abuse. This workstream based approach utilizes the high-resolution, accurate-mass Thermo Scientific Q Exactive Plus Orbitrap mass spectrometer. Identified drugs are screened against an extensive HRAM MS/MS spectral library and a database containing molecular formula, exact mass, retention times, and fragment ions.
Part 2: Thermo Scientific TraceFinder Software Overview and Implementation of a Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer for the Identification and Quantitation of Synthetic Cannabinoids in Postmortem Forensic Investigations. Synthetic cannabinoids continue to appear in forensic toxicology casework, and they represent a chemically diverse class of substances with particularly difficult behaviors to which high resolution mass spectrometry (HRMS) can provide great benefit. A quantitative confirmatory test was developed and validated for 5F-MDMB-PICA (the most prevalent synthetic cannabinoid identified in forensic casework) and its metabolites in human blood. A Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer was used for analysis. This interactive presentation will provide an overview of TraceFinder software along with a review of the performance characteristics to demonstrate the utility and accuracy of the developed assay.
Deb Bhattacharyya, PhD Senior Manager, Vertical Marketing Thermo Fisher Scientific
Kristine Van Natta, PhD Strategic Marketing Applications Specialist Thermo Fisher Scientific
Tais Regina Fiorentin, PhD Research Scientist II The Center for Forensic Science Research and Education
Alex Krotulski, PhD Research Scientist III The Center for Forensic Science Research and Education