Advancing Quantitative Measures of Monocyte Response to Infection from Academic Pursuit to Clinical Practice:

The Time Is Now

  • Date/Time: This special symposium was broadcast during the all-virtual 2020 Annual Scientific Meeting & Clinical Lab Expo, on Monday, December 14, 2020. Registered meeting attendees can now access the session on-demand through January 18, 2021.
  • Format: One program chair and two additional faculty presented portions of the program before closing with prerecorded Q&A.

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Session Description

The goal of this special symposium is to provide a foundation of physiology and current research on monocyte biology and discuss the clinical evidence that is leading to new applications. There is also a need to understand emerging applications and broader use in emergency departments. Throughout the program, there is an underlying need to emphasize the role of laboratorians in communicating and educating clinician counterparts.

Monocytes are the key component of the innate immune response to infection, exhibiting complex, time-dependent differentiating behavior. Monocyte distribution width (MDW), a quantitative measure of variability in monocyte morphology, has recently received regulatory clearance for diagnosis of adult sepsis in the emergency department and has been studied in other patient types, including those emerging in the current COVID-19 pandemic. The goal of the session is to connect current understanding of monocyte hematopathology with current evidence and practical aspects of use in the clinical practice across patient presentations.

What You Will Learn

At the end of this activity, participants will be able to:

  • Discuss monocyte biology including immune-phenotypical and morphological changes in infections and other reactive conditions.
  • Apply clinical evidence and incorporate practical aspects of using monocyte distribution width (MDW) for sepsis diagnostics in the emergency department setting.
  • Understand the role of laboratory champions in educating physicians and improving prevailing practice.
  • Summarize the emerging evidence and ongoing research investigating the role of monocyte morphology in clinical decision-making across infectious and inflammatory presentations.


  • Chair: Magdalena Czader, MD, PhD, Indiana University
  • Jailan Osman, MD, Columbia VA Health Care System
  • Daniel Irimia, MD, PhD, Harvard Medical School

ACCENT® Accreditation

AACC designates this activity for a maximum of 1.5 ACCENT® credit hours towards the AACC Clinical Chemist’s Recognition Award. AACC is an approved provider of continuing education (CE) for clinical laboratory scientists licensed in states that require documentation of CE, including California, Florida, Louisiana, Montana, Nevada, North Dakota, Rhode Island, Tennessee, and West Virginia. ACCENT® credit is also recognized by several organizations: AAB, ABCC, ACS, AMT, ASCLS, ASCP, ASM, CAP, IFCC, and NRCC.

Thank You for Making 2020 AACC a Success

Thank you to all of the top-notch speakers, abstract authors, and exhibitors who have shared their innovations and insights at this year’s meeting—as well as the attendees, whose camaraderie and engagement have made this meeting such a success.

Supported By

Beckman Coulter

This activity is supported by Beckman Coulter, Inc.